I haven't done this, but it seems like it could work:
Do you know how to script a simple contact form? Like when the site user goes to the Contact Us page, they can type their question and hit submit, and behind the scenes that post gets sent to an email address that the user never finds out about.
Well, how about for all the addresses throughout the site, you made them links with the visible text being the people's names or some kinds of IDs that wouldn't help a spammer know anything about their email addresses, and when a user clicks on any of these links, it takes them to a page with a Contact form, but the form has the idea of the "referring link" as a hidden input in the page, so that when the form gets posted you can figure out which email address to send it to.
I think I'd do this if I had my own huge company website to work with.