Technically, no. A BLOB is a BINARY Large Object. Blobs are usually not used to store text, thus it really doesn't make sense to do a text search on a blob.
Of course, there could be text embedded in the blob, such as track data in an mp3. But still, I doubt any database supports text searching in a binary large object. To do this, you will probably need to stream the binary data and search it yourself.
The other kind of LOB is a CLOB, character large object. Whether or not you can do a text search on a CLOB will be database dependent. I know Oracle 9i supports some
string functions for CLOB data. You will need to check your specific database to see if you can do text search on a CLOB.