Hi Greg,
Yes, as a matter of fact chapter 13 (Grails integration) discusses how you can setup a Griffon front-end for a Grails powered back-end using a REST approach to communicate both ends.
The revised edition of the same chapter (not the one currently available in MEAP) points you to
SOAP resources as well.
The Griffon Plugins page has pointers to several options at your disposal for establishing communication with the outside world:
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http://griffon.codehaus.org/Rest+Plugin: lightweight REST client
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http://griffon.codehaus.org/Wsclient+Plugin: SOAP client
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http://griffon.codehaus.org/Xmlrpc+Plugin
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http://griffon.codehaus.org/Jabber+Plugin
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http://griffon.codehaus.org/Rmi+Plugin
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http://griffon.codehaus.org/Hessian+Plugin
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http://griffon.codehaus.org/Jml+Plugin: Microsoft's Messenger protocol
Related plugins:
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http://griffon.codehaus.org/Protobuf+Plugin: Google's protocol buffers
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http://griffon.codehaus.org/Avro+Plugin: custom serialization format/protocol
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http://griffon.codehaus.org/Thrift+Plugin: custom serialization format/protocol
Cheers,
Andres