Consider taking a new look at your CV. I find the key is that it must stand out from other CVs otherwise you'll get lost in the massive pile of applications that they receive. You've got to appear different as there are plenty of people out there with your same qualifications/background and you've got to stand out. How to do this though is tricky, but if you give me your email I'll send you mine - I dont appear to have a problem getting interest for jobs. Also sign up for as many agencies as you can, they'll help you with your cv and usually find plenty of opportunties! try jobserve.co.uk, reed.co.uk, cwjobs.co.uk etc. Good luck!!